Symlin Question
My mom has been on me lately to ask my new endo (who I'll see in January) about Symlin. She thinks it's ideal for me because I haven't seen a big improvement in my control since starting the pump (but it's only been since May and I've had a pretty shoddy endo the entire time...), and I go through periods where I seem to be hungry all the time. Evenings are the worst for me. It's like I don't want to stop eating until I go to sleep.
My question is for those of you out there who have tried or who are trying Symlin. How did/does it work for you? Do you love it? Hate it? Did it work?
Any feedback or info would be helpful!!!
Thank you in advance for your comments...
posted by LaLa at 1:20 PM
4 Comments:
Hello LaLa....Symlin basically slows down the gastric absorption of food. So, it acts by slowing down your digestion. Similar in a way if you had Gastroparesis which many people w/long standing T1DM are prone to develop. Obviously thise that do have Gastroparesis are advised by both their physician and the company that this drug should not be taken. Here is the official info on Symlin:
Pramlintide is a synthetic (man-made) hormone that resembles human amylin. Amylin is a hormone that is produced by the pancreas and released into the blood after meals where it helps the body to regulate levels of blood glucose. Amylin acts in several ways to control blood glucose. It slows the rate at which food (including glucose) is absorbed from the intestine. Amylin reduces the production of glucose by the liver by inhibiting the action of glucagon, a hormone produced by the pancreas that regulates the production of glucose by the liver. Amylin also reduces appetite. In studies, pramlintide-treated patients achieved lower blood glucose levels and experienced weight loss. Pramlintide was approved by the FDA in March, 2005.
Symlin basically slows down your gastric absorption of food. Those with Gastroparesis which is common in long standing T1DM are advised NOT TO TAKE this drug, since they already have a slowing down of their digestion. Here is the official info about this drug:
Pramlintide is a synthetic (man-made) hormone that resembles human amylin. Amylin is a hormone that is produced by the pancreas and released into the blood after meals where it helps the body to regulate levels of blood glucose. Amylin acts in several ways to control blood glucose. It slows the rate at which food (including glucose) is absorbed from the intestine. Amylin reduces the production of glucose by the liver by inhibiting the action of glucagon, a hormone produced by the pancreas that regulates the production of glucose by the liver. Amylin also reduces appetite. In studies, pramlintide-treated patients achieved lower blood glucose levels and experienced weight loss. Pramlintide was approved by the FDA in March, 2005.
I was on Symlin for awhile (I'm off now since I'm TTC and it hasn't be tested in pregnancy). I LOVED it!!
I had to use extended boluses and combo boluses with it though. It took a little playing with, but I learned that about 30% upfront, rest extended over 2 hours worked best for me. If I took my bolus all upfront, I'd be low within 20 minutes.
I didn't notice weight loss with it, but might also not have taken it long enough.
Bettercell - Thanks for the info! Very helpful stuff as I try to decide whether or not to mention it to my endo...! Have you used Symlin at all?
Sarah - If I may ask, what were your reasons for starting Symlin? Thanks for the feedback! I'll have to remember about maybe adjusting my boluses using the combo bolus...! Good tip!!!
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